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+This household accommodates only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, apart from histone, quite a few non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα),  [legal practice](https://linkatjf.com/delleg881) nuclear issue kappaB (NFκB), and  [lawyer article](https://badak3ikar.com/author/coryzhang19680/) elements of the TATA binding protein (TBP) complicated, TBP-associated elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Okay (goal lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of [eradicating](https://careers.tu-varna.bg/employer/hmt/) the methyl mark on most of those substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a traditional mannequin for dynamic lysine methylation of each histone and non-histone proteins.
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